The physician orders alteplase (Activase) for a 58-year-old man diagnosed with an acute ischemic stroke. Which nursing action is most appropriate?

A. Administer the medication by an IV route at 15 mL/hr for 24 hours.
B. Insert two or three large-bore IV catheters before administering the medication.
C. If gingival bleeding occurs, discontinue the medication and notify the physician.
D. Reduce the medication infusion rate for a systolic blood pressure above 180 mm Hg.